Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD_proxy	tier2	1.26e-01	9.08e-02	1.52e-03	9.47e-05
tier2	AD_proxy	4.85e-01	2.74e-01	2.70e-03	3.65e-03



Evaluating how well AD_proxy genes are linked to tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_proxy	tier2	0.68	2.11	2.24	2.16	4.13
tier2	AD_proxy	0.58	0.66	1.51	1.80	2.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD_proxy	tier2	0.01	7.95	10.31	8.51	8.29
tier2	AD_proxy	0.02	28.59	35.11	28.11	33.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD_proxy	95	92	KDM5D;SERPINA3;TMEM265
tier2	46	43	IGH;TNSF13;TNSF12