Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADproxy Exclusive	tier1_tier2	3.07e-05	3.88e-05	8.35e-07	3.39e-07
tier1_tier2 Exclusive	ADproxy	3.27e-01	2.63e-01	3.38e-02	5.19e-03
ADproxy Exclusive	tier1_tier2 Exclusive	1.28e-04	6.40e-04	9.63e-06	5.19e-06
tier1_tier2 Exclusive	ADproxy Exclusive	5.85e-01	2.46e-01	7.32e-02	1.25e-02
ADproxy Exclusive	Overlap	8.74e-03	8.41e-03	8.74e-03	2.47e-03
tier1_tier2 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	3.16e-10	4.19e-10	5.96e-25	3.93e-12



Evaluating how well ADproxy genes are linked to tier1_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADproxy Exclusive	tier1_tier2	0.71	3.41	4.01	3.34	6.26
tier1_tier2 Exclusive	ADproxy	0.59	0.87	1.80	2.32	2.69
ADproxy Exclusive	tier1_tier2 Exclusive	0.70	3.25	3.62	2.72	5.23
tier1_tier2 Exclusive	ADproxy Exclusive	0.57	0.44	1.30	1.39	2.48
ADproxy Exclusive	Overlap	0.95	2.79	2.85	2.34	3.31
tier1_tier2 Exclusive	Overlap	1.00	3.03	2.84	2.90	3.63
Overlap	Exclusives	0.69	5.41	7.62	3.97	9.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADproxy Exclusive	tier1_tier2	0.05	38.29	63.67	53.23	32.21
tier1_tier2 Exclusive	ADproxy	0.05	76.19	80.03	38.23	78.61
ADproxy Exclusive	tier1_tier2 Exclusive	0.04	37.50	50.90	39.02	22.45
tier1_tier2 Exclusive	ADproxy Exclusive	0.03	33.69	47.31	44.61	57.85
ADproxy Exclusive	Overlap	0.02	34.39	77.83	44.98	69.21
tier1_tier2 Exclusive	Overlap	0.15	118.81	101.16	419.96	353.38
Overlap	Exclusives	0.10	71.36	137.99	61.06	151.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADproxy Exclusive	91	88	KDM5D;TMEM265;SERPINA3
tier1_tier2 Exclusive	73	69	MS4A;TNSF13;IGH;TNSF12
Overlap	4	4