Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD	Ismael	1.25e-04	5.55e-06	2.29e-06	3.91e-07
Ismael	AD	2.07e-01	2.31e-01	3.50e-05	1.57e-02



Evaluating how well AD genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD	Ismael	0.91	2.48	4.99	3.10	4.95
Ismael	AD	0.59	3.94	2.22	2.28	3.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD	Ismael	0.01	5.79	17.19	6.21	10.96
Ismael	AD	0.01	2.86	3.41	2.78	2.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD	101	101	
Ismael	14	14