Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) AD Ismael 1.25e-04 5.55e-06 2.29e-06 3.91e-07 Ismael AD 2.07e-01 2.31e-01 3.50e-05 1.57e-02 Evaluating how well AD genes are linked to Ismael genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) AD Ismael 0.91 2.48 4.99 3.10 4.95 Ismael AD 0.59 3.94 2.22 2.28 3.04 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) AD Ismael 0.01 5.79 17.19 6.21 10.96 Ismael AD 0.01 2.86 3.41 2.78 2.28 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes AD 101 101 Ismael 14 14