Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FTD	Ismael	2.64e-02	4.51e-02	3.05e-02	2.29e-01
Ismael	FTD	3.47e-03	1.50e-02	2.73e-02	4.53e-02



Evaluating how well FTD genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FTD	Ismael	0.50	-1.66	-1.91	-1.49	0.12
Ismael	FTD	0.45	-1.89	-2.86	-1.96	-1.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FTD	Ismael	0.00	-0.99	-0.64	-0.82	-0.47
Ismael	FTD	0.00	-1.19	-1.69	-1.30	-1.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FTD	63	62	AC018554.3
Ismael	14	14