Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
FTD	GWAS	6.26e-01	9.39e-01	9.19e-01	2.43e-02
GWAS	FTD	3.27e-01	4.25e-01	3.84e-01	8.26e-01



Evaluating how well FTD genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FTD	GWAS	0.57	0.20	0.44	0.09	2.23
GWAS	FTD	0.50	0.34	0.20	0.05	0.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
FTD	GWAS	0.01	-0.19	-0.07	-0.33	0.33
GWAS	FTD	0.00	0.04	-0.17	-0.13	-0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
FTD	63	62	AC018554.3
GWAS	109	104	MIR302F;SLC8A1-AS1;PCDH11Y;LINC00158;D21S2088E