Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS	5.02e-07	1.56e-05	1.18e-05	5.81e-10
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	3.96e-01	1.13e-02	7.27e-03	1.47e-02
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS Exclusive	9.32e-07	1.24e-05	3.31e-06	1.70e-08
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	4.08e-01	1.75e-02	1.53e-02	4.24e-02
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	9.11e-02	1.81e-01	1.37e-01	5.19e-02
TIER1_GS Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	2.74e-08
Overlap	Exclusives	2.89e-02	1.15e-03	3.23e-14	1.41e-04



Evaluating how well EUR_stats_related_clean_AD_ADC_HC_selected_1_185 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS	0.82	3.92	5.37	3.26	6.47
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.55	2.69	3.52	3.07	2.94
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS Exclusive	0.82	4.33	6.25	3.53	6.01
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	0.54	2.59	3.15	2.37	2.70
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	0.81	2.13	1.81	1.62	2.27
TIER1_GS Exclusive	Overlap	1.00	3.20	3.38	2.69	3.32
Overlap	Exclusives	0.57	3.01	4.96	2.64	3.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS	0.01	6.04	7.53	2.52	7.20
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.02	8.57	16.32	13.92	12.80
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	TIER1_GS Exclusive	0.00	7.39	7.20	4.96	7.25
TIER1_GS Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	0.02	6.42	9.94	6.26	7.23
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	0.00	4.67	4.51	1.30	0.28
TIER1_GS Exclusive	Overlap	0.09	366.35	264.35	260.03	413.09
Overlap	Exclusives	0.05	36.09	51.20	30.23	42.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	254	250	CHURC1-FNTB;AC093512.2;AC006059.2;EDDM13
TIER1_GS Exclusive	27	26	MS4A
Overlap	4	4