Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185	Ismael_14_AD	6.53e-02	2.45e-01	5.73e-02	2.37e-03
Ismael_14_AD	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	1.13e-01	1.22e-01	4.91e-10	1.07e-01



Evaluating how well EUR_stats_related_clean_AD_ADC_HC_selected_1_185 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185	Ismael_14_AD	0.78	1.67	2.09	1.36	3.40
Ismael_14_AD	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.54	3.24	2.72	2.39	2.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185	Ismael_14_AD	0.01	3.33	0.52	3.04	13.23
Ismael_14_AD	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.02	2.67	3.62	2.53	1.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_stats_related_clean_AD_ADC_HC_selected_1_185	258	254	CHURC1-FNTB;AC093512.2;AC006059.2;EDDM13
Ismael_14_AD	14	14