Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs	1.89e-01	1.27e-01	1.13e-01	1.44e-04
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	2.17e-01	4.21e-02	1.19e-05	2.38e-02
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs Exclusive	2.00e-01	9.39e-02	9.47e-02	2.32e-04
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	2.63e-01	5.32e-02	1.81e-05	1.67e-02
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	5.74e-01	9.11e-01	6.53e-01	1.00e+00
tier2_gs Exclusive	Overlap	1.58e-01	1.78e-01	3.96e-02	1.39e-01
Overlap	Exclusives	2.50e-04	4.85e-01	2.16e-17	8.02e-02



Evaluating how well EUR_stats_related_clean_AD_ADC_HC_selected_1_185 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs	0.70	2.27	3.14	2.22	4.59
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.54	2.93	2.25	1.94	2.20
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs Exclusive	0.70	2.56	3.32	2.43	3.81
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	0.54	2.54	2.10	2.26	2.45
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	0.54	-0.61	-0.35	-0.53	0.03
tier2_gs Exclusive	Overlap	0.95	1.37	1.63	1.62	1.60
Overlap	Exclusives	0.54	0.53	1.00	0.66	2.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs	0.01	2.53	3.21	2.66	5.34
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185	0.02	7.88	7.26	6.55	6.37
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	tier2_gs Exclusive	0.01	2.32	2.86	3.70	1.67
tier2_gs Exclusive	EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	0.02	7.41	7.14	6.50	7.17
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	Overlap	0.00	-0.33	-0.34	-0.46	-0.25
tier2_gs Exclusive	Overlap	0.00	0.52	1.50	1.97	0.31
Overlap	Exclusives	0.02	0.26	0.41	0.31	1.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_stats_related_clean_AD_ADC_HC_selected_1_185 Exclusive	257	253	AC093512.2;AC006059.2;EDDM13;CHURC1-FNTB
tier2_gs Exclusive	45	42	IGH;TNSF13;TNSF12
Overlap	1	1