Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_regulome_Score152 Exclusive	tier1_31	1.46e-10	2.78e-09	3.77e-11	4.13e-11
tier1_31 Exclusive	sigma_regulome_Score152	3.52e-02	9.90e-02	4.03e-03	1.38e-02
sigma_regulome_Score152 Exclusive	tier1_31 Exclusive	1.02e-08	3.44e-08	1.02e-09	5.29e-09
tier1_31 Exclusive	sigma_regulome_Score152 Exclusive	1.15e-01	2.02e-01	1.06e-02	3.32e-02
sigma_regulome_Score152 Exclusive	Overlap	3.98e-03	4.36e-07	1.43e-03	2.96e-04
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	7.54e-05	1.71e-04	1.77e-13	1.29e-04



Evaluating how well sigma_regulome_Score152 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_Score152 Exclusive	tier1_31	0.85	4.41	6.39	4.17	6.39
tier1_31 Exclusive	sigma_regulome_Score152	0.58	1.91	2.07	2.21	4.03
sigma_regulome_Score152 Exclusive	tier1_31 Exclusive	0.84	3.55	5.23	3.70	5.80
tier1_31 Exclusive	sigma_regulome_Score152 Exclusive	0.57	1.49	1.89	1.94	3.05
sigma_regulome_Score152 Exclusive	Overlap	0.98	2.39	2.81	2.49	2.89
tier1_31 Exclusive	Overlap	1.00	2.81	2.20	2.81	2.87
Overlap	Exclusives	0.61	3.00	4.32	2.28	5.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_Score152 Exclusive	tier1_31	0.04	51.97	82.11	63.77	77.24
tier1_31 Exclusive	sigma_regulome_Score152	0.02	15.18	21.08	10.65	16.00
sigma_regulome_Score152 Exclusive	tier1_31 Exclusive	0.04	52.33	73.89	54.64	48.23
tier1_31 Exclusive	sigma_regulome_Score152 Exclusive	0.02	6.51	13.89	12.69	8.44
sigma_regulome_Score152 Exclusive	Overlap	0.01	13.93	34.60	10.93	12.87
tier1_31 Exclusive	Overlap	0.04	88.78	122.51	163.47	35.28
Overlap	Exclusives	0.04	39.31	46.00	25.11	50.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_regulome_Score152 Exclusive	149	143	CLEC20A;CCDC187;AC233992.2;AC010197.2;MARCOL;SPECC1L-ADORA2A
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3