Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_regulome_100 Exclusive	tier1_31	2.96e-06	3.62e-06	1.72e-07	1.22e-09
tier1_31 Exclusive	sigma_regulome_100	1.14e-01	2.98e-01	1.89e-02	1.19e-01
sigma_regulome_100 Exclusive	tier1_31 Exclusive	1.66e-05	4.85e-06	2.52e-07	7.56e-09
tier1_31 Exclusive	sigma_regulome_100 Exclusive	2.24e-01	7.59e-01	1.06e-01	1.94e-01
sigma_regulome_100 Exclusive	Overlap	1.32e-01	1.15e-01	9.07e-02	1.90e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.70e-05	1.13e-04	4.57e-10	7.73e-05



Evaluating how well sigma_regulome_100 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_100 Exclusive	tier1_31	0.85	4.17	5.86	3.59	6.71
tier1_31 Exclusive	sigma_regulome_100	0.57	1.00	1.17	1.62	2.34
sigma_regulome_100 Exclusive	tier1_31 Exclusive	0.84	4.77	6.84	3.73	7.05
tier1_31 Exclusive	sigma_regulome_100 Exclusive	0.56	0.95	0.67	0.99	1.75
sigma_regulome_100 Exclusive	Overlap	0.91	1.95	2.17	2.31	2.69
tier1_31 Exclusive	Overlap	1.00	2.91	2.92	2.34	2.79
Overlap	Exclusives	0.64	3.70	4.88	2.37	5.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_regulome_100 Exclusive	tier1_31	0.01	14.93	24.38	10.11	19.25
tier1_31 Exclusive	sigma_regulome_100	0.02	18.89	6.37	19.97	22.40
sigma_regulome_100 Exclusive	tier1_31 Exclusive	0.01	14.51	21.99	7.18	13.30
tier1_31 Exclusive	sigma_regulome_100 Exclusive	0.01	9.24	4.61	8.75	4.77
sigma_regulome_100 Exclusive	Overlap	0.00	2.15	5.06	4.86	6.10
tier1_31 Exclusive	Overlap	0.04	98.76	144.57	86.65	106.34
Overlap	Exclusives	0.04	44.37	26.97	20.29	45.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_regulome_100 Exclusive	97	92	AC233992.2;MARCOL;SPECC1L-ADORA2A;CLEC20A;AC010197.2
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3