Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	tier2_gs	1.61e-02	8.44e-04	2.04e-03	7.03e-05
tier2_gs	ADC cases and excluding AMISH  and APOE4 controls_51	7.82e-02	5.50e-02	6.46e-03	1.83e-02



Evaluating how well ADC cases and excluding AMISH  and APOE4 controls_51 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	tier2_gs	0.71	1.87	3.09	2.77	4.43
tier2_gs	ADC cases and excluding AMISH  and APOE4 controls_51	0.62	3.07	2.36	2.12	2.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	tier2_gs	0.01	1.92	4.17	3.41	4.35
tier2_gs	ADC cases and excluding AMISH  and APOE4 controls_51	0.02	40.11	22.09	47.42	51.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC cases and excluding AMISH  and APOE4 controls_51	51	49	CHURC1-FNTB;EDDM13
tier2_gs	46	43	TNSF12;TNSF13;IGH