Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	Ismael_14_AD	9.39e-02	3.81e-02	3.41e-02	1.10e-04
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_51	6.59e-01	1.40e-01	3.05e-04	4.08e-02



Evaluating how well ADC cases and excluding AMISH  and APOE4 controls_51 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	Ismael_14_AD	0.80	1.96	3.10	1.67	3.58
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_51	0.60	1.96	2.20	2.00	2.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_51	Ismael_14_AD	0.00	3.39	4.72	1.54	6.15
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_51	0.00	1.04	2.73	1.76	3.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC cases and excluding AMISH  and APOE4 controls_51	51	49	EDDM13;CHURC1-FNTB
Ismael_14_AD	14	14