Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116	Ismael_14_AD	6.53e-02	1.46e-01	1.02e-01	2.98e-03
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_116	3.03e-01	4.48e-02	1.48e-07	6.56e-02



Evaluating how well ADC cases and excluding AMISH  and APOE4 controls_116 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116	Ismael_14_AD	0.80	2.10	2.78	1.85	3.85
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_116	0.56	3.98	2.59	2.80	2.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116	Ismael_14_AD	0.01	6.91	14.38	4.28	5.94
Ismael_14_AD	ADC cases and excluding AMISH  and APOE4 controls_116	0.01	3.56	3.65	3.71	2.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC cases and excluding AMISH  and APOE4 controls_116	116	114	CHURC1-FNTB;EDDM13
Ismael_14_AD	14	14