Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs	1.32e-02	2.71e-03	9.30e-03	1.14e-04
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116	1.91e-01	3.18e-01	3.34e-03	2.71e-01
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs Exclusive	2.35e-02	5.31e-03	1.53e-02	7.62e-05
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	2.60e-01	4.35e-01	2.85e-03	4.04e-01
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	Overlap	9.78e-01	9.64e-01	9.00e-01	8.40e-01
tier2_gs Exclusive	Overlap	5.55e-01	6.27e-01	6.10e-01	5.37e-01
Overlap	Exclusives	2.16e-07	1.25e-03	1.83e-01	6.35e-05



Evaluating how well ADC cases and excluding AMISH  and APOE4 controls_116 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs	0.70	2.17	3.79	2.42	4.23
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116	0.55	2.99	1.90	2.42	1.73
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs Exclusive	0.71	2.62	3.10	2.66	4.62
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	0.55	3.06	1.79	1.78	1.70
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	Overlap	0.45	-0.03	-0.06	0.13	-0.06
tier2_gs Exclusive	Overlap	0.53	1.05	0.59	1.24	0.08
Overlap	Exclusives	0.60	1.77	4.13	2.35	5.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs	0.01	4.31	10.91	5.30	6.66
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116	0.01	5.10	7.18	5.08	3.08
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	tier2_gs Exclusive	0.01	4.57	9.03	4.81	1.78
tier2_gs Exclusive	ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	0.01	9.22	6.85	7.89	3.65
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	Overlap	0.00	-0.28	-0.42	-0.25	-0.20
tier2_gs Exclusive	Overlap	0.00	-0.10	0.08	0.13	0.55
Overlap	Exclusives	0.01	1.61	2.74	3.21	3.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC cases and excluding AMISH  and APOE4 controls_116 Exclusive	114	112	CHURC1-FNTB;EDDM13
tier2_gs Exclusive	44	41	TNSF12;TNSF13;IGH
Overlap	2	2