Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy Exclusive	GoldStandards	5.25e-01	4.90e-02	6.95e-05	1.39e-05
GoldStandards Exclusive	Cauchy	1.30e-02	8.76e-02	1.01e-11	8.93e-11
Cauchy Exclusive	GoldStandards Exclusive	6.88e-01	1.64e-01	1.09e-03	2.75e-04
GoldStandards Exclusive	Cauchy Exclusive	3.19e-02	1.79e-01	2.16e-11	2.63e-10
Cauchy Exclusive	Overlap	5.29e-02	2.96e-01	1.49e-02	6.42e-02
GoldStandards Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.58e-01	2.93e-01	2.00e-08	3.90e-10



Evaluating how well Cauchy genes are linked to GoldStandards genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.84	-0.00	2.33	1.62	4.39
GoldStandards Exclusive	Cauchy	0.67	1.92	2.35	1.85	8.73
Cauchy Exclusive	GoldStandards Exclusive	0.88	0.80	2.21	1.96	4.46
GoldStandards Exclusive	Cauchy Exclusive	0.66	1.40	1.74	1.54	6.64
Cauchy Exclusive	Overlap	0.72	-1.02	0.56	0.56	1.35
GoldStandards Exclusive	Overlap	1.00	3.61	2.67	2.61	3.13
Overlap	Exclusives	0.66	1.04	2.03	1.00	7.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.00	-0.35	2.15	2.50	2.04
GoldStandards Exclusive	Cauchy	0.02	5.19	5.95	7.67	17.94
Cauchy Exclusive	GoldStandards Exclusive	0.00	-0.08	2.21	2.77	3.70
GoldStandards Exclusive	Cauchy Exclusive	0.02	1.60	1.19	2.37	5.48
Cauchy Exclusive	Overlap	0.00	-0.64	-0.03	-0.06	0.00
GoldStandards Exclusive	Overlap	0.24	2174.72	380.35	127.66	403.19
Overlap	Exclusives	0.02	3.25	4.10	2.69	11.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy Exclusive	180	180	
GoldStandards Exclusive	8	8	
Overlap	3	3