Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy Exclusive	GoldStandards	5.05e-01	2.92e-02	7.18e-05	2.37e-05
GoldStandards Exclusive	Cauchy	1.12e-02	8.21e-02	3.42e-12	1.66e-11
Cauchy Exclusive	GoldStandards Exclusive	5.86e-01	2.24e-01	9.90e-04	2.75e-04
GoldStandards Exclusive	Cauchy Exclusive	4.40e-02	1.71e-01	4.17e-12	1.42e-10
Cauchy Exclusive	Overlap	4.78e-02	4.41e-01	1.34e-02	8.78e-02
GoldStandards Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.61e-01	4.08e-01	1.99e-06	9.94e-11



Evaluating how well Cauchy genes are linked to GoldStandards genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.84	-0.06	2.07	1.68	4.00
GoldStandards Exclusive	Cauchy	0.67	1.80	2.09	2.21	8.95
Cauchy Exclusive	GoldStandards Exclusive	0.88	1.02	2.22	1.96	3.82
GoldStandards Exclusive	Cauchy Exclusive	0.66	1.45	1.89	1.52	8.64
Cauchy Exclusive	Overlap	0.72	-1.03	0.34	0.57	1.17
GoldStandards Exclusive	Overlap	1.00	3.66	2.75	2.79	2.94
Overlap	Exclusives	0.66	1.08	1.58	0.71	8.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.00	-0.51	2.15	2.24	0.57
GoldStandards Exclusive	Cauchy	0.02	5.03	4.78	8.04	11.41
Cauchy Exclusive	GoldStandards Exclusive	0.00	0.07	2.45	2.85	0.67
GoldStandards Exclusive	Cauchy Exclusive	0.02	1.67	1.43	2.88	7.82
Cauchy Exclusive	Overlap	0.00	-0.63	-0.24	-0.11	-0.11
GoldStandards Exclusive	Overlap	0.24	2055.24	343.91	738.70	574.07
Overlap	Exclusives	0.02	3.54	3.61	2.01	10.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy Exclusive	180	180	
GoldStandards Exclusive	8	8	
Overlap	3	3