Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy Exclusive	GoldStandards	5.80e-01	5.16e-02	9.88e-05	2.92e-05
GoldStandards Exclusive	Cauchy	1.14e-02	6.90e-02	5.53e-11	2.30e-11
Cauchy Exclusive	GoldStandards Exclusive	7.12e-01	2.14e-01	4.38e-04	4.38e-04
GoldStandards Exclusive	Cauchy Exclusive	3.32e-02	1.57e-01	2.28e-11	9.76e-11
Cauchy Exclusive	Overlap	8.78e-02	2.75e-01	2.28e-02	6.83e-02
GoldStandards Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.38e-01	4.04e-01	2.91e-07	1.88e-10



Evaluating how well Cauchy genes are linked to GoldStandards genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.84	-0.02	2.19	1.56	3.72
GoldStandards Exclusive	Cauchy	0.67	1.81	2.74	1.85	7.82
Cauchy Exclusive	GoldStandards Exclusive	0.88	0.73	2.34	2.17	3.72
GoldStandards Exclusive	Cauchy Exclusive	0.66	1.31	2.08	1.75	8.21
Cauchy Exclusive	Overlap	0.72	-1.06	0.53	0.61	1.35
GoldStandards Exclusive	Overlap	1.00	3.61	2.95	2.48	3.18
Overlap	Exclusives	0.66	1.08	1.65	0.82	7.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy Exclusive	GoldStandards	0.00	-0.42	2.32	1.93	5.86
GoldStandards Exclusive	Cauchy	0.02	5.91	5.56	7.84	15.51
Cauchy Exclusive	GoldStandards Exclusive	0.00	-0.16	2.86	3.00	4.20
GoldStandards Exclusive	Cauchy Exclusive	0.02	1.42	1.36	3.14	7.77
Cauchy Exclusive	Overlap	0.00	-0.86	-0.05	-0.06	0.00
GoldStandards Exclusive	Overlap	0.24	1818.79	386.67	364.64	1642.56
Overlap	Exclusives	0.02	3.58	2.91	2.79	8.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy Exclusive	180	180	
GoldStandards Exclusive	8	8	
Overlap	3	3