Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31	1.63e-02	3.00e-03	1.45e-03	1.51e-04
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1	2.23e-01	6.08e-01	9.09e-02	2.45e-01
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31 Exclusive	4.24e-02	1.18e-02	4.19e-03	2.90e-04
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	3.30e-01	9.69e-01	3.22e-01	4.57e-01
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	Overlap	4.94e-01	1.27e-01	3.11e-01	1.45e-01
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.29e-05	3.19e-05	7.90e-10	9.50e-06



Evaluating how well All Excluding Young_regolumescore_z_3_5_tier1 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31	0.73	2.20	3.74	2.55	3.90
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1	0.56	0.89	0.62	0.87	1.55
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31 Exclusive	0.72	1.79	3.37	2.10	4.18
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	0.53	0.18	-0.13	0.55	0.82
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	Overlap	0.81	1.04	1.04	1.37	2.18
tier1_31 Exclusive	Overlap	1.00	2.84	2.57	2.58	3.22
Overlap	Exclusives	0.68	4.91	5.81	3.58	5.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31	0.00	2.68	3.25	2.97	3.93
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1	0.01	8.57	11.77	10.76	2.45
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	tier1_31 Exclusive	0.00	2.00	2.49	1.71	2.66
tier1_31 Exclusive	All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	0.00	0.45	2.14	3.15	3.79
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	Overlap	0.00	0.52	0.67	0.59	1.88
tier1_31 Exclusive	Overlap	0.04	111.22	137.78	100.83	186.84
Overlap	Exclusives	0.04	22.96	61.40	34.69	63.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All Excluding Young_regolumescore_z_3_5_tier1 Exclusive	59	54	CLEC20A;AC233992.2;AC010197.2;MARCOL;SPECC1L-ADORA2A
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3