Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
overlap_score_binary_121	diff_score_binary_31	5.24e-01	6.14e-01	3.39e-01	5.47e-01
diff_score_binary_31	overlap_score_binary_121	4.80e-01	2.01e-01	6.91e-01	2.51e-02



Evaluating how well overlap_score_binary_121 genes are linked to diff_score_binary_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap_score_binary_121	diff_score_binary_31	0.54	1.34	1.55	1.43	0.52
diff_score_binary_31	overlap_score_binary_121	0.57	0.98	1.18	1.35	3.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap_score_binary_121	diff_score_binary_31	0.00	0.68	-0.22	0.06	0.23
diff_score_binary_31	overlap_score_binary_121	0.01	0.99	1.53	1.47	1.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
overlap_score_binary_121	121	116	AC010197.2;AC233992.2;MARCOL;SPECC1L-ADORA2A;CCDC187
diff_score_binary_31	31	30	CLEC20A