Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
overlap_score_binary_121	diff_binary_score_47	6.15e-01	9.42e-01	9.66e-01	9.10e-01
diff_binary_score_47	overlap_score_binary_121	9.65e-01	8.19e-01	9.42e-01	1.79e-01



Evaluating how well overlap_score_binary_121 genes are linked to diff_binary_score_47 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap_score_binary_121	diff_binary_score_47	0.51	-0.11	0.16	-0.14	0.14
diff_binary_score_47	overlap_score_binary_121	0.54	0.50	-0.05	0.14	1.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap_score_binary_121	diff_binary_score_47	0.00	0.17	1.52	0.02	0.37
diff_binary_score_47	overlap_score_binary_121	0.01	0.10	-0.31	-0.29	0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
overlap_score_binary_121	121	116	AC010197.2;CCDC187;AC233992.2;MARCOL;SPECC1L-ADORA2A
diff_binary_score_47	47	45	C13orf46;AL845331.2