Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
31different genes	Overlap_121	2.54e-01	1.66e-01	6.20e-01	1.18e-02
Overlap_121	31different genes	6.26e-01	5.35e-01	3.25e-01	4.83e-01



Evaluating how well 31different genes genes are linked to Overlap_121 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
31different genes	Overlap_121	0.57	1.47	1.37	1.48	2.60
Overlap_121	31different genes	0.54	1.16	1.55	1.46	0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
31different genes	Overlap_121	0.01	1.64	1.39	0.67	1.96
Overlap_121	31different genes	0.00	0.05	-0.12	0.36	0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
31different genes	31	30	CLEC20A
Overlap_121	121	116	SPECC1L-ADORA2A;AC010197.2;MARCOL;CCDC187;AC233992.2