Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
47different genes	Overlap_121	9.24e-01	8.52e-01	8.97e-01	1.68e-01
Overlap_121	47different genes	5.08e-01	9.02e-01	9.75e-01	9.17e-01



Evaluating how well 47different genes genes are linked to Overlap_121 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
47different genes	Overlap_121	0.54	0.56	0.02	0.25	1.82
Overlap_121	47different genes	0.51	-0.24	-0.01	-0.27	0.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
47different genes	Overlap_121	0.01	0.14	-0.32	-0.19	0.31
Overlap_121	47different genes	0.00	0.13	0.59	-0.02	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
47different genes	47	45	C13orf46;AL845331.2
Overlap_121	121	116	AC010197.2;CCDC187;MARCOL;SPECC1L-ADORA2A;AC233992.2