Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31	9.54e-12	8.16e-12	1.88e-12	3.56e-13
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37	1.62e-01	2.28e-01	3.17e-02	3.73e-02
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31 Exclusive	9.17e-12	8.20e-11	4.43e-12	1.05e-11
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37 Exclusive	3.89e-01	2.94e-01	1.07e-01	3.41e-02
All Excluding Young_regolume_z_4_37 Exclusive	Overlap	1.80e-01	5.17e-01	1.92e-01	5.53e-02
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	8.85e-06	1.13e-07	2.17e-14	1.28e-07



Evaluating how well All Excluding Young_regolume_z_4_37 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31	0.90	5.60	7.73	4.64	7.32
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37	0.65	3.04	2.38	2.35	2.92
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31 Exclusive	0.90	5.93	7.45	4.39	7.10
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37 Exclusive	0.63	1.96	2.24	2.41	3.03
All Excluding Young_regolume_z_4_37 Exclusive	Overlap	0.91	2.11	1.55	1.64	1.99
tier1_31 Exclusive	Overlap	1.00	2.53	1.67	2.06	2.38
Overlap	Exclusives	0.75	5.17	6.51	3.36	6.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31	0.04	73.42	86.68	30.66	65.86
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37	0.02	41.44	44.68	36.90	38.33
All Excluding Young_regolume_z_4_37 Exclusive	tier1_31 Exclusive	0.04	81.59	72.19	41.68	122.73
tier1_31 Exclusive	All Excluding Young_regolume_z_4_37 Exclusive	0.01	30.90	40.81	30.33	35.68
All Excluding Young_regolume_z_4_37 Exclusive	Overlap	0.00	9.26	8.13	11.00	0.25
tier1_31 Exclusive	Overlap	0.02	23.51	38.56	49.02	65.52
Overlap	Exclusives	0.02	23.46	41.47	16.58	10.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All Excluding Young_regolume_z_4_37 Exclusive	35	34	AC010197.2
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2