Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31	1.24e-03	1.93e-03	2.96e-03	6.90e-05
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33	4.60e-01	5.66e-01	2.97e-01	3.42e-01
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31 Exclusive	3.12e-04	7.21e-04	6.06e-04	4.70e-05
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33 Exclusive	8.39e-01	6.51e-01	3.12e-01	4.98e-01
All Excluding Young_regolumescore_z_4_33 Exclusive	Overlap	7.52e-01	5.17e-01	8.04e-01	2.81e-01
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	5.91e-04
Overlap	Exclusives	4.44e-05	4.17e-06	9.99e-15	2.30e-06



Evaluating how well All Excluding Young_regolumescore_z_4_33 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31	0.76	2.69	4.71	2.16	4.76
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33	0.56	1.32	1.42	1.50	1.38
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31 Exclusive	0.76	2.95	4.85	2.49	4.88
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33 Exclusive	0.53	0.92	0.86	0.78	0.56
All Excluding Young_regolumescore_z_4_33 Exclusive	Overlap	0.78	1.00	0.62	0.82	1.46
tier1_31 Exclusive	Overlap	1.00	2.71	1.66	2.27	2.47
Overlap	Exclusives	0.71	4.57	6.73	3.27	5.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31	0.00	4.13	5.35	2.21	2.75
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33	0.01	8.33	15.79	10.48	16.03
All Excluding Young_regolumescore_z_4_33 Exclusive	tier1_31 Exclusive	0.00	5.05	3.81	2.43	0.52
tier1_31 Exclusive	All Excluding Young_regolumescore_z_4_33 Exclusive	0.00	3.05	4.84	3.58	3.07
All Excluding Young_regolumescore_z_4_33 Exclusive	Overlap	0.00	0.43	1.69	0.02	-0.03
tier1_31 Exclusive	Overlap	0.02	40.14	35.89	40.96	25.06
Overlap	Exclusives	0.02	22.54	36.01	5.32	21.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All Excluding Young_regolumescore_z_4_33 Exclusive	31	29	MARCOL;AC010197.2
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2