Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC samples_36 Exclusive	tier1_31	5.85e-07	9.12e-09	2.06e-07	1.72e-09
tier1_31 Exclusive	ADC samples_36	3.33e-01	4.93e-01	1.54e-01	2.68e-01
ADC samples_36 Exclusive	tier1_31 Exclusive	4.46e-07	8.59e-08	5.60e-08	6.42e-09
tier1_31 Exclusive	ADC samples_36 Exclusive	6.12e-01	9.45e-01	6.47e-01	6.68e-01
ADC samples_36 Exclusive	Overlap	1.50e-01	2.49e-02	1.45e-01	5.47e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	5.10e-07	5.74e-07	3.88e-14	8.23e-09



Evaluating how well ADC samples_36 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36 Exclusive	tier1_31	0.79	3.21	6.27	2.52	6.04
tier1_31 Exclusive	ADC samples_36	0.59	0.89	0.82	1.05	1.85
ADC samples_36 Exclusive	tier1_31 Exclusive	0.79	3.68	5.28	3.82	5.73
tier1_31 Exclusive	ADC samples_36 Exclusive	0.55	0.24	0.30	0.32	1.00
ADC samples_36 Exclusive	Overlap	0.80	1.55	1.39	1.14	1.63
tier1_31 Exclusive	Overlap	1.00	3.31	2.59	2.65	2.63
Overlap	Exclusives	0.73	4.53	5.17	3.53	5.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36 Exclusive	tier1_31	0.00	2.11	5.92	0.67	2.26
tier1_31 Exclusive	ADC samples_36	0.01	17.82	15.81	15.68	14.01
ADC samples_36 Exclusive	tier1_31 Exclusive	0.00	4.08	3.96	4.16	2.62
tier1_31 Exclusive	ADC samples_36 Exclusive	0.00	2.56	2.35	3.27	1.02
ADC samples_36 Exclusive	Overlap	0.00	0.30	0.20	0.18	0.28
tier1_31 Exclusive	Overlap	0.04	192.41	115.89	119.02	54.39
Overlap	Exclusives	0.04	73.83	79.90	44.65	22.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC samples_36 Exclusive	33	33	
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3