Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC samples_36	Ismael_14_AD	1.24e-02	4.19e-05	3.75e-04	2.35e-05
Ismael_14_AD	ADC samples_36	1.77e-01	5.52e-01	1.39e-02	2.26e-01



Evaluating how well ADC samples_36 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36	Ismael_14_AD	0.85	2.18	4.46	2.12	5.16
Ismael_14_AD	ADC samples_36	0.61	4.15	1.46	1.55	2.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36	Ismael_14_AD	0.01	5.65	24.88	10.27	12.86
Ismael_14_AD	ADC samples_36	0.00	6.36	4.03	2.96	5.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC samples_36	36	36	
Ismael_14_AD	14	14