Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC samples_36	tier2_gs	4.75e-02	3.55e-03	3.28e-03	6.58e-04
tier2_gs	ADC samples_36	3.39e-02	9.80e-02	2.87e-03	2.48e-02



Evaluating how well ADC samples_36 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36	tier2_gs	0.71	3.04	3.94	3.07	5.00
tier2_gs	ADC samples_36	0.59	1.73	1.00	1.21	1.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC samples_36	tier2_gs	0.01	5.12	10.33	6.31	5.75
tier2_gs	ADC samples_36	0.03	115.22	64.00	22.40	76.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC samples_36	36	36	
tier2_gs	46	43	TNSF13;IGH;TNSF12