Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS 6.03e-08 3.15e-08 6.47e-08 1.68e-09 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 2.99e-01 3.57e-01 4.53e-02 4.24e-01 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS Exclusive 4.46e-07 9.26e-08 3.36e-07 1.48e-08 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 2.29e-01 3.35e-01 6.70e-02 5.29e-01 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 6.83e-02 2.04e-01 1.45e-01 1.90e-02 TIER1_GS Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-06 Overlap Exclusives 1.36e-03 6.95e-05 5.77e-13 3.10e-05 Evaluating how well ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 genes are linked to TIER1_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS 0.83 3.27 5.63 3.43 6.71 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 0.53 1.02 1.23 1.38 1.32 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS Exclusive 0.82 3.06 5.12 3.22 6.51 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 0.52 0.75 1.01 0.81 0.67 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 0.93 2.31 2.16 2.10 2.77 TIER1_GS Exclusive Overlap 1.00 3.28 2.58 2.74 3.09 Overlap Exclusives 0.62 4.41 5.76 2.92 5.75 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS 0.01 9.28 22.03 12.08 19.34 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 0.02 16.23 22.15 22.29 15.09 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive TIER1_GS Exclusive 0.01 11.18 14.88 15.10 1.57 TIER1_GS Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 0.02 13.12 16.77 15.14 15.79 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 0.00 4.98 2.35 4.32 0.58 TIER1_GS Exclusive Overlap 0.04 144.55 149.97 81.38 51.52 Overlap Exclusives 0.04 45.70 38.48 20.59 42.61 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 132 130 CHURC1-FNTB;EDDM13 TIER1_GS Exclusive 28 27 MS4A Overlap 3 3