Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs 1.10e-01 1.41e-02 4.47e-02 1.23e-04 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 1.39e-01 2.16e-01 1.41e-03 9.56e-02 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs Exclusive 1.08e-01 4.55e-03 2.19e-02 1.16e-04 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 1.79e-01 2.36e-01 1.85e-03 1.70e-01 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 6.27e-01 6.77e-01 5.55e-01 8.82e-01 tier2_gs Exclusive Overlap 5.55e-01 6.44e-01 5.37e-01 5.92e-01 Overlap Exclusives 2.07e-07 4.34e-03 6.66e-02 3.87e-04 Evaluating how well ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 genes are linked to tier2_gs genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs 0.69 2.19 3.31 2.24 4.51 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 0.54 2.67 1.62 1.84 1.64 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs Exclusive 0.70 1.80 3.48 2.72 4.78 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 0.54 2.66 1.83 1.93 2.17 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 0.55 0.91 0.43 1.01 0.20 tier2_gs Exclusive Overlap 0.53 1.08 0.64 0.96 0.24 Overlap Exclusives 0.58 1.81 3.70 1.92 3.80 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs 0.01 2.79 6.62 3.35 5.37 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 0.01 3.57 4.21 3.63 5.80 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive tier2_gs Exclusive 0.01 2.08 6.86 3.56 5.28 tier2_gs Exclusive ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 0.01 5.66 4.42 3.56 6.26 ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive Overlap 0.00 -0.25 -0.41 -0.20 -0.24 tier2_gs Exclusive Overlap 0.00 -0.08 0.08 0.89 0.70 Overlap Exclusives 0.01 1.58 1.79 2.36 2.92 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes ADC Cohort other HC excluding cohorts of APOE4 young WRAP AMISH APOE44_135 Exclusive 133 131 EDDM13;CHURC1-FNTB tier2_gs Exclusive 44 41 TNSF13;TNSF12;IGH Overlap 2 2