Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	Ismael_14_AD	3.43e-01	5.84e-01	4.08e-01	2.16e-02
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	8.98e-01	6.58e-02	5.80e-06	7.93e-02



Evaluating how well ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	Ismael_14_AD	0.73	1.21	1.31	0.97	3.20
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	0.55	3.17	2.56	2.00	2.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	Ismael_14_AD	0.00	1.99	3.31	1.61	3.81
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	0.01	1.19	2.01	1.07	1.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_135	135	133	EDDM13;CHURC1-FNTB
Ismael_14_AD	14	14