Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	tier2_gs	7.08e-02	5.47e-02	9.11e-03	8.58e-05
tier2_gs	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	5.17e-01	5.79e-01	9.98e-03	8.06e-02



Evaluating how well ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	tier2_gs	0.68	1.97	2.69	2.43	4.22
tier2_gs	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	0.59	1.83	1.39	1.96	2.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	tier2_gs	0.01	3.19	5.86	4.76	6.15
tier2_gs	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	0.02	39.93	20.17	46.36	47.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	57	55	EDDM13;CHURC1-FNTB
tier2_gs	46	43	TNSF12;IGH;TNSF13