Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	Ismael_14_AD	1.20e-02	1.70e-02	2.86e-03	8.17e-05
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	6.76e-01	6.45e-02	2.76e-03	6.23e-03



Evaluating how well ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	Ismael_14_AD	0.82	2.33	3.22	1.93	3.83
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	0.61	2.90	2.01	2.30	3.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	Ismael_14_AD	0.00	7.65	9.01	2.64	3.89
Ismael_14_AD	ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	0.00	3.32	2.94	2.67	2.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC Cohort other HC excluding cohorts of APOE4  young WRAP  AMISH APOE44_57	57	55	CHURC1-FNTB;EDDM13
Ismael_14_AD	14	14