Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_88 Exclusive	tier1_31	3.41e-04	8.07e-05	1.92e-05	8.27e-07
tier1_31 Exclusive	ADC_88	3.01e-01	6.24e-01	9.90e-02	1.51e-01
ADC_88 Exclusive	tier1_31 Exclusive	1.45e-03	2.66e-04	3.61e-04	3.70e-05
tier1_31 Exclusive	ADC_88 Exclusive	2.26e-01	8.97e-01	2.32e-01	2.47e-01
ADC_88 Exclusive	Overlap	1.19e-01	1.86e-01	6.03e-02	8.54e-03
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.52e-05
Overlap	Exclusives	9.74e-05	1.75e-05	1.55e-15	8.60e-08



Evaluating how well ADC_88 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88 Exclusive	tier1_31	0.75	2.54	4.12	2.42	5.63
tier1_31 Exclusive	ADC_88	0.56	0.87	0.93	1.00	1.97
ADC_88 Exclusive	tier1_31 Exclusive	0.74	2.42	3.73	1.96	3.83
tier1_31 Exclusive	ADC_88 Exclusive	0.55	0.43	0.50	0.79	1.48
ADC_88 Exclusive	Overlap	0.87	1.85	1.88	1.84	2.52
tier1_31 Exclusive	Overlap	1.00	2.83	2.51	2.51	2.74
Overlap	Exclusives	0.66	5.31	5.09	3.18	5.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88 Exclusive	tier1_31	0.00	2.52	5.25	1.89	4.72
tier1_31 Exclusive	ADC_88	0.01	8.33	9.47	7.74	8.91
ADC_88 Exclusive	tier1_31 Exclusive	0.00	2.72	4.66	1.30	1.57
tier1_31 Exclusive	ADC_88 Exclusive	0.01	1.79	1.78	1.49	2.23
ADC_88 Exclusive	Overlap	0.00	0.18	2.48	0.42	0.19
tier1_31 Exclusive	Overlap	0.04	81.33	119.51	135.59	12.46
Overlap	Exclusives	0.03	44.77	44.80	23.22	21.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_88 Exclusive	85	84	CHURC1-FNTB
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3