Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_88	tier2_gs	3.15e-01	2.24e-01	7.42e-02	5.73e-04
tier2_gs	ADC_88	3.70e-01	2.18e-01	7.81e-03	1.88e-01



Evaluating how well ADC_88 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88	tier2_gs	0.67	1.90	1.89	1.91	3.63
tier2_gs	ADC_88	0.55	0.47	0.47	0.76	2.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88	tier2_gs	0.01	2.54	4.52	3.54	7.35
tier2_gs	ADC_88	0.02	23.95	20.22	21.88	23.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_88	88	87	CHURC1-FNTB
tier2_gs	46	43	IGH;TNSF12;TNSF13