Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_88	Ismael_14_AD	5.84e-01	2.53e-01	1.46e-01	3.04e-03
Ismael_14_AD	ADC_88	2.95e-01	5.83e-01	1.06e-04	6.89e-02



Evaluating how well ADC_88 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88	Ismael_14_AD	0.74	0.83	1.96	1.07	3.16
Ismael_14_AD	ADC_88	0.56	1.69	0.73	1.09	1.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_88	Ismael_14_AD	0.00	3.08	12.68	4.28	12.87
Ismael_14_AD	ADC_88	0.01	2.95	1.18	1.87	0.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_88	88	87	CHURC1-FNTB
Ismael_14_AD	14	14