Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_selected_4_118 Exclusive	TIER1_GS	5.00e-01	5.53e-01	3.55e-01	1.77e-02
TIER1_GS Exclusive	sigma_selected_4_118	3.94e-02	6.70e-01	2.63e-01	5.01e-01
sigma_selected_4_118 Exclusive	TIER1_GS Exclusive	8.64e-01	6.74e-01	7.13e-01	8.62e-02
TIER1_GS Exclusive	sigma_selected_4_118 Exclusive	1.95e-02	4.73e-01	3.32e-01	4.97e-01
sigma_selected_4_118 Exclusive	Overlap	3.98e-01	4.41e-01	4.76e-01	9.71e-02
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	2.07e-03	7.27e-04	7.16e-12	5.04e-05



Evaluating how well sigma_selected_4_118 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118 Exclusive	TIER1_GS	0.62	0.66	0.67	0.53	2.28
TIER1_GS Exclusive	sigma_selected_4_118	0.52	0.08	-0.04	0.26	0.59
sigma_selected_4_118 Exclusive	TIER1_GS Exclusive	0.61	0.38	0.78	0.32	1.83
TIER1_GS Exclusive	sigma_selected_4_118 Exclusive	0.51	-0.37	-0.37	-0.31	0.48
sigma_selected_4_118 Exclusive	Overlap	0.74	1.01	0.85	0.70	1.50
TIER1_GS Exclusive	Overlap	1.00	2.92	2.79	2.56	2.94
Overlap	Exclusives	0.62	4.46	4.61	3.29	4.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118 Exclusive	TIER1_GS	0.00	-0.13	-0.49	-0.17	0.57
TIER1_GS Exclusive	sigma_selected_4_118	0.01	2.73	2.64	1.65	3.06
sigma_selected_4_118 Exclusive	TIER1_GS Exclusive	0.00	-0.19	-0.34	-0.27	0.03
TIER1_GS Exclusive	sigma_selected_4_118 Exclusive	0.01	-0.41	-0.40	-0.35	-0.02
sigma_selected_4_118 Exclusive	Overlap	0.00	0.14	0.29	-0.09	0.65
TIER1_GS Exclusive	Overlap	0.04	87.30	178.38	171.25	108.23
Overlap	Exclusives	0.03	34.20	25.54	22.89	20.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_selected_4_118 Exclusive	115	114	EDDM13
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3