Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_selected_4_118	tier2_gs	6.60e-01	3.02e-01	2.37e-01	6.62e-03
tier2_gs	sigma_selected_4_118	7.60e-01	3.41e-01	5.57e-03	2.27e-01



Evaluating how well sigma_selected_4_118 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118	tier2_gs	0.66	1.12	2.05	1.88	4.01
tier2_gs	sigma_selected_4_118	0.55	1.51	1.12	1.39	2.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118	tier2_gs	0.00	0.57	2.21	1.87	2.42
tier2_gs	sigma_selected_4_118	0.02	13.36	10.85	16.94	12.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_selected_4_118	118	117	EDDM13
tier2_gs	46	43	TNSF13;IGH;TNSF12