Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_selected_4_118	Ismael_14_AD	7.11e-01	8.18e-01	4.47e-01	2.95e-02
Ismael_14_AD	sigma_selected_4_118	3.88e-01	5.83e-01	1.61e-04	3.33e-01



Evaluating how well sigma_selected_4_118 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118	Ismael_14_AD	0.70	0.29	0.32	0.71	2.66
Ismael_14_AD	sigma_selected_4_118	0.54	2.09	1.28	1.11	1.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_118	Ismael_14_AD	0.00	0.25	1.02	0.64	1.55
Ismael_14_AD	sigma_selected_4_118	0.01	0.90	0.81	0.92	0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_selected_4_118	118	117	EDDM13
Ismael_14_AD	14	14