Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_selected_4_54 Exclusive	TIER1_GS	9.67e-03	2.88e-03	3.17e-02	2.17e-04
TIER1_GS Exclusive	sigma_selected_4_54	2.46e-01	1.91e-01	7.65e-02	1.77e-01
sigma_selected_4_54 Exclusive	TIER1_GS Exclusive	8.45e-03	1.90e-03	2.56e-02	2.28e-04
TIER1_GS Exclusive	sigma_selected_4_54 Exclusive	5.32e-01	3.84e-01	2.75e-01	5.90e-01
sigma_selected_4_54 Exclusive	Overlap	3.34e-01	6.03e-01	3.90e-01	1.36e-01
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	8.73e-07	1.71e-07	2.46e-12	1.74e-07



Evaluating how well sigma_selected_4_54 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_54 Exclusive	TIER1_GS	0.73	1.93	3.81	1.94	4.28
TIER1_GS Exclusive	sigma_selected_4_54	0.53	1.35	0.77	0.70	0.65
sigma_selected_4_54 Exclusive	TIER1_GS Exclusive	0.72	1.72	3.67	2.29	4.03
TIER1_GS Exclusive	sigma_selected_4_54 Exclusive	0.50	0.32	0.25	0.18	-0.03
sigma_selected_4_54 Exclusive	Overlap	0.82	1.43	1.44	1.36	2.09
TIER1_GS Exclusive	Overlap	1.00	3.14	2.75	2.48	2.94
Overlap	Exclusives	0.69	4.92	6.74	3.75	5.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_54 Exclusive	TIER1_GS	0.00	1.44	3.68	1.56	2.96
TIER1_GS Exclusive	sigma_selected_4_54	0.01	10.17	12.95	6.91	6.38
sigma_selected_4_54 Exclusive	TIER1_GS Exclusive	0.00	1.01	2.96	1.61	2.63
TIER1_GS Exclusive	sigma_selected_4_54 Exclusive	0.00	0.70	2.26	0.86	0.71
sigma_selected_4_54 Exclusive	Overlap	0.00	1.27	2.43	1.26	0.04
TIER1_GS Exclusive	Overlap	0.04	153.73	191.04	165.84	85.02
Overlap	Exclusives	0.04	47.43	67.46	39.29	54.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_selected_4_54 Exclusive	51	50	EDDM13
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3