Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_selected_4_54	tier2_gs	3.77e-02	7.93e-04	7.12e-03	7.99e-05
tier2_gs	sigma_selected_4_54	7.06e-01	8.22e-01	7.03e-02	6.25e-01



Evaluating how well sigma_selected_4_54 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_54	tier2_gs	0.67	1.61	2.31	2.07	3.84
tier2_gs	sigma_selected_4_54	0.55	1.52	0.78	1.15	1.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_selected_4_54	tier2_gs	0.00	1.89	4.41	2.50	4.21
tier2_gs	sigma_selected_4_54	0.02	35.91	23.13	29.98	28.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_selected_4_54	54	53	EDDM13
tier2_gs	46	43	IGH;TNSF12;TNSF13