Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_42 Exclusive	tier1_31	3.53e-11	3.87e-11	5.13e-12	1.60e-13
tier1_31 Exclusive	selected_2_42	3.20e-02	8.65e-02	8.86e-03	2.76e-02
selected_2_42 Exclusive	tier1_31 Exclusive	1.28e-09	2.17e-10	1.20e-09	5.10e-11
tier1_31 Exclusive	selected_2_42 Exclusive	1.51e-01	3.23e-01	7.53e-02	2.41e-01
selected_2_42 Exclusive	Overlap	4.78e-02	7.71e-02	6.03e-02	1.99e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	1.74e-06	8.71e-06
Overlap	Exclusives	1.40e-09	3.08e-10	2.70e-13	9.27e-11



Evaluating how well selected_2_42 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	tier1_31	0.89	5.48	7.78	5.37	8.57
tier1_31 Exclusive	selected_2_42	0.60	2.43	2.13	2.38	2.15
selected_2_42 Exclusive	tier1_31 Exclusive	0.89	4.41	7.83	5.00	7.28
tier1_31 Exclusive	selected_2_42 Exclusive	0.57	1.95	1.61	1.55	1.20
selected_2_42 Exclusive	Overlap	0.93	2.17	2.48	2.29	2.49
tier1_31 Exclusive	Overlap	1.00	3.15	2.63	2.72	2.68
Overlap	Exclusives	0.74	5.69	7.61	3.65	6.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	tier1_31	0.03	40.78	69.19	36.23	46.16
tier1_31 Exclusive	selected_2_42	0.02	42.23	7.55	43.63	7.42
selected_2_42 Exclusive	tier1_31 Exclusive	0.02	13.29	42.92	35.13	17.69
tier1_31 Exclusive	selected_2_42 Exclusive	0.01	22.79	2.55	3.68	21.56
selected_2_42 Exclusive	Overlap	0.01	19.03	25.34	25.72	8.88
tier1_31 Exclusive	Overlap	0.04	151.70	177.12	75.97	52.24
Overlap	Exclusives	0.05	62.70	18.96	37.73	94.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_42 Exclusive	39	37	RTEL1-TNFRSF6B;TNFSF12-TNFSF13
tier1_31 Exclusive	28	26	MS4A;SLC24A4å
Overlap	3	3