Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_42 Exclusive	tier2_gs	3.64e-02	1.34e-03	6.76e-03	4.62e-04
tier2_gs Exclusive	selected_2_42	3.35e-01	4.31e-01	1.38e-01	5.49e-01
selected_2_42 Exclusive	tier2_gs Exclusive	2.89e-02	8.94e-04	1.01e-02	1.21e-04
tier2_gs Exclusive	selected_2_42 Exclusive	5.59e-01	7.92e-01	2.05e-01	7.67e-01
selected_2_42 Exclusive	Overlap	4.55e-01	6.73e-01	4.95e-01	6.93e-01
tier2_gs Exclusive	Overlap	1.98e-02	1.98e-02	5.94e-02	5.94e-02
Overlap	Exclusives	2.05e-03	9.31e-02	4.15e-02	3.64e-04



Evaluating how well selected_2_42 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	tier2_gs	0.68	2.00	3.21	2.52	4.36
tier2_gs Exclusive	selected_2_42	0.54	1.23	0.92	0.90	1.08
selected_2_42 Exclusive	tier2_gs Exclusive	0.68	2.03	2.91	2.60	4.37
tier2_gs Exclusive	selected_2_42 Exclusive	0.53	1.31	0.30	0.49	0.72
selected_2_42 Exclusive	Overlap	0.68	1.08	0.65	0.84	0.67
tier2_gs Exclusive	Overlap	0.99	2.39	2.30	2.03	1.52
Overlap	Exclusives	0.63	1.40	2.85	1.36	3.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	tier2_gs	0.00	3.53	5.90	3.17	4.00
tier2_gs Exclusive	selected_2_42	0.03	78.22	80.09	76.55	37.56
selected_2_42 Exclusive	tier2_gs Exclusive	0.00	3.02	5.31	3.73	3.64
tier2_gs Exclusive	selected_2_42 Exclusive	0.03	87.37	61.30	82.88	59.28
selected_2_42 Exclusive	Overlap	0.00	-0.06	-0.23	-0.17	-0.14
tier2_gs Exclusive	Overlap	0.00	17.47	8.98	0.54	0.02
Overlap	Exclusives	0.01	2.37	6.73	2.60	3.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_42 Exclusive	41	39	TNFSF12-TNFSF13;RTEL1-TNFRSF6B
tier2_gs Exclusive	45	42	TNSF13;IGH;TNSF12
Overlap	1	1