Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_42 Exclusive	Ismael_14_AD	1.09e-02	4.38e-03	1.11e-02	7.31e-04
Ismael_14_AD Exclusive	selected_2_42	2.56e-01	3.33e-01	8.17e-04	1.55e-01
selected_2_42 Exclusive	Ismael_14_AD Exclusive	9.14e-03	1.71e-03	1.36e-02	5.59e-04
Ismael_14_AD Exclusive	selected_2_42 Exclusive	4.41e-01	4.22e-01	2.15e-03	2.72e-01
selected_2_42 Exclusive	Overlap	4.55e-01	6.53e-01	2.97e-01	6.34e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.73e-03	7.58e-04	2.01e-03	1.18e-03



Evaluating how well selected_2_42 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	Ismael_14_AD	0.81	2.06	3.82	1.94	4.28
Ismael_14_AD Exclusive	selected_2_42	0.59	3.91	2.10	1.97	2.22
selected_2_42 Exclusive	Ismael_14_AD Exclusive	0.82	1.88	4.50	1.69	4.27
Ismael_14_AD Exclusive	selected_2_42 Exclusive	0.58	3.25	2.23	1.58	1.75
selected_2_42 Exclusive	Overlap	0.68	1.09	0.63	1.02	0.64
Ismael_14_AD Exclusive	Overlap	1.00	4.70	2.02	2.49	1.82
Overlap	Exclusives	0.65	1.65	3.37	1.71	4.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_42 Exclusive	Ismael_14_AD	0.00	7.00	11.76	1.80	4.95
Ismael_14_AD Exclusive	selected_2_42	0.01	45.29	24.76	17.34	15.47
selected_2_42 Exclusive	Ismael_14_AD Exclusive	0.00	4.93	21.97	3.46	1.73
Ismael_14_AD Exclusive	selected_2_42 Exclusive	0.00	7.71	6.30	2.15	2.55
selected_2_42 Exclusive	Overlap	0.00	0.10	-0.28	-0.16	-0.21
Ismael_14_AD Exclusive	Overlap	0.25	18662.82	1104.55	195.43	1346.92
Overlap	Exclusives	0.03	19.97	75.11	30.44	64.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_42 Exclusive	41	39	RTEL1-TNFRSF6B;TNFSF12-TNFSF13
Ismael_14_AD Exclusive	13	13	
Overlap	1	1