Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_115 Exclusive	tier1_31	1.95e-10	1.34e-11	1.73e-10	1.79e-12
tier1_31 Exclusive	selected_2_115	2.40e-01	4.26e-01	7.85e-02	3.19e-01
selected_2_115 Exclusive	tier1_31 Exclusive	1.10e-08	6.80e-10	2.37e-09	1.53e-10
tier1_31 Exclusive	selected_2_115 Exclusive	5.04e-01	6.13e-01	2.35e-01	4.60e-01
selected_2_115 Exclusive	Overlap	6.18e-03	2.44e-05	7.06e-03	1.98e-04
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	8.55e-07	2.45e-08	8.66e-15	2.82e-08



Evaluating how well selected_2_115 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	tier1_31	0.85	4.27	6.88	4.04	6.60
tier1_31 Exclusive	selected_2_115	0.55	1.52	1.52	1.53	1.82
selected_2_115 Exclusive	tier1_31 Exclusive	0.84	3.57	5.82	3.98	6.28
tier1_31 Exclusive	selected_2_115 Exclusive	0.54	1.26	1.04	1.19	1.53
selected_2_115 Exclusive	Overlap	0.98	2.88	2.59	2.92	2.73
tier1_31 Exclusive	Overlap	1.00	2.83	2.37	2.73	3.02
Overlap	Exclusives	0.64	5.95	6.60	3.89	5.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	tier1_31	0.04	30.21	115.02	69.11	92.36
tier1_31 Exclusive	selected_2_115	0.03	20.98	36.70	41.83	32.96
selected_2_115 Exclusive	tier1_31 Exclusive	0.03	55.08	63.94	31.01	35.61
tier1_31 Exclusive	selected_2_115 Exclusive	0.03	34.90	44.18	40.11	36.01
selected_2_115 Exclusive	Overlap	0.01	13.46	43.41	35.71	13.26
tier1_31 Exclusive	Overlap	0.04	135.33	153.41	219.22	9.24
Overlap	Exclusives	0.05	29.50	55.10	39.75	60.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_115 Exclusive	112	108	RTEL1-TNFRSF6B;TMEM191C;TNFSF12-TNFSF13;AC113554.1
tier1_31 Exclusive	28	26	SLC24A4å;MS4A
Overlap	3	3