Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_115 Exclusive	tier2_gs	8.15e-02	1.24e-02	6.49e-02	8.54e-04
tier2_gs Exclusive	selected_2_115	6.55e-02	1.66e-01	1.52e-03	1.30e-01
selected_2_115 Exclusive	tier2_gs Exclusive	1.19e-01	1.31e-02	4.15e-02	3.61e-04
tier2_gs Exclusive	selected_2_115 Exclusive	1.01e-01	2.00e-01	2.01e-03	1.78e-01
selected_2_115 Exclusive	Overlap	8.71e-01	8.32e-01	9.50e-01	5.35e-01
tier2_gs Exclusive	Overlap	1.98e-02	5.94e-02	3.96e-02	3.96e-02
Overlap	Exclusives	4.34e-04	1.82e-01	1.14e-01	4.95e-03



Evaluating how well selected_2_115 genes are linked to tier2_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	tier2_gs	0.69	2.70	3.73	2.31	4.19
tier2_gs Exclusive	selected_2_115	0.57	3.23	2.13	2.16	2.44
selected_2_115 Exclusive	tier2_gs Exclusive	0.70	2.46	3.70	2.88	4.82
tier2_gs Exclusive	selected_2_115 Exclusive	0.56	2.85	2.17	1.95	2.09
selected_2_115 Exclusive	Overlap	0.30	-0.41	-0.59	-0.46	-0.74
tier2_gs Exclusive	Overlap	0.99	2.29	1.76	2.02	1.63
Overlap	Exclusives	0.59	1.80	2.45	1.64	3.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	tier2_gs	0.01	6.41	10.53	5.55	6.87
tier2_gs Exclusive	selected_2_115	0.02	11.56	22.45	21.19	22.07
selected_2_115 Exclusive	tier2_gs Exclusive	0.01	6.09	12.10	6.22	9.36
tier2_gs Exclusive	selected_2_115 Exclusive	0.02	23.81	18.42	20.50	16.71
selected_2_115 Exclusive	Overlap	0.00	-0.22	-0.30	-0.14	-0.33
tier2_gs Exclusive	Overlap	0.00	7.20	2.18	1.62	7.39
Overlap	Exclusives	0.01	1.92	4.87	1.72	3.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_115 Exclusive	114	110	TNFSF12-TNFSF13;RTEL1-TNFRSF6B;TMEM191C;AC113554.1
tier2_gs Exclusive	45	42	TNSF13;TNSF12;IGH
Overlap	1	1