Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_115 Exclusive	Ismael_14_AD	1.93e-01	2.61e-01	2.53e-01	1.41e-02
Ismael_14_AD Exclusive	selected_2_115	6.33e-01	4.90e-01	9.21e-06	2.85e-01
selected_2_115 Exclusive	Ismael_14_AD Exclusive	2.74e-01	1.60e-01	1.47e-01	8.97e-03
Ismael_14_AD Exclusive	selected_2_115 Exclusive	5.30e-01	5.53e-01	1.09e-06	4.47e-01
selected_2_115 Exclusive	Overlap	9.31e-01	9.50e-01	8.71e-01	6.53e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.33e-04	4.05e-02	1.94e-01	2.24e-03



Evaluating how well selected_2_115 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	Ismael_14_AD	0.69	0.78	0.37	0.42	2.34
Ismael_14_AD Exclusive	selected_2_115	0.55	2.23	1.35	1.38	1.60
selected_2_115 Exclusive	Ismael_14_AD Exclusive	0.72	0.61	0.91	0.58	2.48
Ismael_14_AD Exclusive	selected_2_115 Exclusive	0.54	1.86	1.22	1.08	1.37
selected_2_115 Exclusive	Overlap	0.30	-0.33	-0.52	-0.51	-0.65
Ismael_14_AD Exclusive	Overlap	1.00	4.40	1.99	2.70	1.52
Overlap	Exclusives	0.59	1.54	2.87	2.01	3.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_115 Exclusive	Ismael_14_AD	0.00	2.69	5.40	1.06	5.79
Ismael_14_AD Exclusive	selected_2_115	0.01	9.81	6.47	5.88	5.51
selected_2_115 Exclusive	Ismael_14_AD Exclusive	0.00	2.36	8.49	2.85	3.27
Ismael_14_AD Exclusive	selected_2_115 Exclusive	0.01	1.15	1.82	1.34	0.36
selected_2_115 Exclusive	Overlap	0.00	-0.36	-0.33	-0.26	-0.43
Ismael_14_AD Exclusive	Overlap	0.25	13842.62	1095.94	553.87	1582.76
Overlap	Exclusives	0.02	5.90	28.05	9.79	9.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_115 Exclusive	114	110	TMEM191C;RTEL1-TNFRSF6B;AC113554.1;TNFSF12-TNFSF13
Ismael_14_AD Exclusive	13	13	
Overlap	1	1