Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31	1.03e-13	1.76e-12	2.37e-14	1.52e-14
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5	8.16e-03	2.46e-02	3.23e-03	7.68e-03
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31 Exclusive	5.04e-13	7.71e-13	2.67e-12	3.66e-13
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5 Exclusive	3.33e-02	3.87e-02	2.00e-02	4.08e-02
ADC_R4_Regulomescore_3_5 Exclusive	Overlap	6.21e-02	5.17e-01	9.75e-02	3.46e-02
tier1_31 Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	5.91e-04
Overlap	Exclusives	2.47e-06	2.70e-08	3.18e-18	3.71e-09



Evaluating how well ADC_R4_Regulomescore_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31	0.90	5.37	7.81	4.63	7.05
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5	0.65	2.59	2.33	2.12	2.98
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31 Exclusive	0.90	6.06	8.71	4.76	7.31
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5 Exclusive	0.63	1.74	2.13	2.03	2.37
ADC_R4_Regulomescore_3_5 Exclusive	Overlap	0.94	2.27	1.92	1.88	2.19
tier1_31 Exclusive	Overlap	1.00	2.59	1.59	2.46	2.56
Overlap	Exclusives	0.77	5.06	7.42	2.94	6.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31	0.02	29.67	61.83	26.86	41.35
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5	0.01	23.68	27.72	17.37	35.39
ADC_R4_Regulomescore_3_5 Exclusive	tier1_31 Exclusive	0.02	16.43	5.02	19.81	18.40
tier1_31 Exclusive	ADC_R4_Regulomescore_3_5 Exclusive	0.01	8.27	22.89	19.63	23.23
ADC_R4_Regulomescore_3_5 Exclusive	Overlap	0.00	20.48	25.70	20.56	10.29
tier1_31 Exclusive	Overlap	0.02	31.06	45.98	96.50	28.68
Overlap	Exclusives	0.02	35.49	44.21	16.32	8.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_R4_Regulomescore_3_5 Exclusive	31	29	PRAMEF15;AC005779.2
tier1_31 Exclusive	29	28	MS4A
Overlap	2	2