Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC_R4_Regulomescore_3 Exclusive	tier1_31	1.01e-05	1.34e-05	2.53e-05	1.09e-08
tier1_31 Exclusive	ADC_R4_Regulomescore_3	5.44e-03	6.43e-03	9.30e-04	4.74e-03
ADC_R4_Regulomescore_3 Exclusive	tier1_31 Exclusive	3.86e-06	1.38e-06	1.90e-06	2.10e-07
tier1_31 Exclusive	ADC_R4_Regulomescore_3 Exclusive	2.66e-02	1.66e-02	8.81e-03	3.51e-02
ADC_R4_Regulomescore_3 Exclusive	Overlap	8.93e-01	8.75e-01	8.87e-01	8.86e-02
tier1_31 Exclusive	Overlap	1.94e-05	1.08e-04	6.40e-08	9.05e-07
Overlap	Exclusives	8.21e-02	2.38e-05	9.17e-22	2.71e-06



Evaluating how well ADC_R4_Regulomescore_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_Regulomescore_3 Exclusive	tier1_31	0.84	4.45	6.69	3.58	6.04
tier1_31 Exclusive	ADC_R4_Regulomescore_3	0.58	3.52	2.85	2.88	3.04
ADC_R4_Regulomescore_3 Exclusive	tier1_31 Exclusive	0.84	4.09	7.02	3.80	6.00
tier1_31 Exclusive	ADC_R4_Regulomescore_3 Exclusive	0.57	3.21	2.41	2.30	2.83
ADC_R4_Regulomescore_3 Exclusive	Overlap	0.80	0.74	0.39	0.57	1.99
tier1_31 Exclusive	Overlap	0.99	2.37	2.55	2.76	3.30
Overlap	Exclusives	0.63	2.57	5.63	2.92	5.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC_R4_Regulomescore_3 Exclusive	tier1_31	0.01	12.83	21.81	10.09	20.58
tier1_31 Exclusive	ADC_R4_Regulomescore_3	0.01	11.17	10.72	10.79	11.86
ADC_R4_Regulomescore_3 Exclusive	tier1_31 Exclusive	0.01	10.51	30.43	11.82	6.01
tier1_31 Exclusive	ADC_R4_Regulomescore_3 Exclusive	0.01	6.44	7.15	5.92	7.44
ADC_R4_Regulomescore_3 Exclusive	Overlap	0.00	6.60	6.69	5.97	10.54
tier1_31 Exclusive	Overlap	0.01	17.47	23.65	50.13	25.84
Overlap	Exclusives	0.01	5.25	8.80	7.15	9.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC_R4_Regulomescore_3 Exclusive	123	118	AC005779.2;ZNF511-PRAP1;PRAMEF15;LINC02210-CRHR1;AP001781.2
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4