Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected2_56 Exclusive	tier1_31	4.65e-11	2.73e-10	8.16e-12	1.15e-12
tier1_31 Exclusive	selected2_56	4.48e-03	3.11e-03	1.81e-04	3.96e-04
selected2_56 Exclusive	tier1_31 Exclusive	2.36e-10	1.58e-10	3.36e-11	6.83e-12
tier1_31 Exclusive	selected2_56 Exclusive	1.78e-02	6.10e-03	1.58e-03	1.82e-03
selected2_56 Exclusive	Overlap	3.82e-01	6.30e-01	4.32e-01	2.28e-02
tier1_31 Exclusive	Overlap	4.36e-06	1.13e-03	4.36e-06	8.71e-06
Overlap	Exclusives	4.59e-05	1.26e-06	2.25e-15	4.80e-08



Evaluating how well selected2_56 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected2_56 Exclusive	tier1_31	0.88	4.52	7.94	5.58	7.22
tier1_31 Exclusive	selected2_56	0.65	3.53	3.11	3.07	3.96
selected2_56 Exclusive	tier1_31 Exclusive	0.88	4.83	8.02	3.94	6.70
tier1_31 Exclusive	selected2_56 Exclusive	0.63	2.95	3.06	3.08	3.72
selected2_56 Exclusive	Overlap	0.87	1.36	1.53	1.41	2.54
tier1_31 Exclusive	Overlap	0.99	2.64	2.03	2.41	3.09
Overlap	Exclusives	0.71	3.02	6.99	2.76	7.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected2_56 Exclusive	tier1_31	0.02	18.68	45.25	20.15	4.08
tier1_31 Exclusive	selected2_56	0.01	17.92	18.23	15.20	21.89
selected2_56 Exclusive	tier1_31 Exclusive	0.01	20.42	28.83	5.93	14.42
tier1_31 Exclusive	selected2_56 Exclusive	0.01	2.46	14.58	12.51	14.35
selected2_56 Exclusive	Overlap	0.00	17.67	7.80	14.60	16.65
tier1_31 Exclusive	Overlap	0.01	38.36	23.78	15.53	57.28
Overlap	Exclusives	0.02	14.56	29.69	8.30	7.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected2_56 Exclusive	53	50	PRAMEF15;AC005779.2;TMEM191C
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3