Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
selected_2_184 Exclusive	tier1_31	1.77e-03	1.37e-04	2.99e-05	2.62e-06
tier1_31 Exclusive	selected_2_184	2.68e-01	7.43e-01	4.00e-01	2.78e-01
selected_2_184 Exclusive	tier1_31 Exclusive	1.50e-03	3.90e-04	4.04e-04	4.71e-05
tier1_31 Exclusive	selected_2_184 Exclusive	2.42e-01	9.65e-01	6.87e-01	6.54e-01
selected_2_184 Exclusive	Overlap	2.80e-01	6.25e-01	2.65e-01	2.16e-02
tier1_31 Exclusive	Overlap	1.57e-10	4.90e-06	1.57e-10	4.61e-08
Overlap	Exclusives	2.15e-03	3.06e-03	2.61e-19	1.23e-03



Evaluating how well selected_2_184 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_184 Exclusive	tier1_31	0.77	2.23	4.72	3.41	5.43
tier1_31 Exclusive	selected_2_184	0.54	0.68	0.68	0.85	2.13
selected_2_184 Exclusive	tier1_31 Exclusive	0.75	2.43	4.27	2.73	4.68
tier1_31 Exclusive	selected_2_184 Exclusive	0.53	0.43	0.32	0.45	1.15
selected_2_184 Exclusive	Overlap	0.85	1.23	1.17	1.28	2.43
tier1_31 Exclusive	Overlap	0.99	3.40	3.23	3.29	3.81
Overlap	Exclusives	0.59	3.90	3.37	3.06	4.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
selected_2_184 Exclusive	tier1_31	0.01	3.82	9.77	7.78	10.06
tier1_31 Exclusive	selected_2_184	0.02	8.52	5.33	6.58	7.18
selected_2_184 Exclusive	tier1_31 Exclusive	0.00	1.55	8.67	4.72	5.98
tier1_31 Exclusive	selected_2_184 Exclusive	0.01	1.91	2.32	2.51	2.57
selected_2_184 Exclusive	Overlap	0.01	8.74	7.54	10.99	13.38
tier1_31 Exclusive	Overlap	0.04	160.86	58.77	154.21	61.01
Overlap	Exclusives	0.06	50.34	44.46	44.80	44.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
selected_2_184 Exclusive	180	173	AC005779.2;TAF11L13;PRAMEF15;TMEM191C;TNFSF12-TNFSF13;LINC02210-CRHR1;AL451062.3
tier1_31 Exclusive	26	25	MS4A
Overlap	5	5